Dieting and the youth of the brain may be linked: Study

February 01, 2016

Mice that were genetically altered to lack CREB1 showed none of the same memory benefits if they were on a low-calorie diet as mice that had the molecule, and showed the same brain disabilities as mice that were over-fed. ???Thus, our findings identify for the first time an important mediator of the effects of diet on the brain,??? Pani explained. ???This discovery has important implications to develop future therapies to keep our brain young and prevent brain degeneration and the ageing process.???

Marc Gordon, chief of neurology at Zucker Hillside Hospital in Glen Oaks, New York, said that the findings could shed new light on why some people who are obese in middle age encounter cognitive problems later in life. ???Mid-life obesity has been associated with late-life dementia. However, the physiological basis for this association remains unclear,??? said Gordon, who was not part of the study. ???These investigators have studied the effects of limiting caloric intake in mice, and have identified a biochemical pathway that may mediate at least some of the brain's responses to dietary restriction.???